List of Interstate Highways in Mississippi
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  Standard route shields | |
Interstate Highways highlighted in red | |
| Highway names | |
|---|---|
| Interstates | Interstate X (I-X) |
| US Highways | U.S. Route X (US X) |
| State | Mississippi Highway X (MS X) |
| System links | |
In the U.S. state of Mississippi, Interstate Highways are maintained by the Mississippi Department of Transportation (MDOT).
Primary highways
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 I-10
|
77.056 | 124.010 | I-10 at Louisiana state line east of Slidell | I-10 at Alabama state line near Missala | — | — | ||
 Future I-14
|
— | — | Future I-14 at the Louisiana Mississippi River|state line near Natchez | Future I-14 at the Alabama state line near Meridian | proposed | — | Proposed across the central part of the state | |
 I-20
|
154.5 | 248.6 | I-20 at the Louisiana state line near Vicksburg | I-20 / I-59 at the Alabama state line near Kewanee | — | — | ||
 I-22
|
106.0 | 170.6 | I-269 / US 78 in Byhalia | I-22 at the Alabama state line east of Tremont | — | — | ||
 I-55
|
290.41 | 467.37 | I-55 at the Louisiana state line near Osyka | I-55 at the Tennessee state line near Southaven | — | — | ||
 I-59
|
169 | 272 | I-59 at the Louisiana state line near Nicholson | I-20 / I-59 at Alabama state line near Kewanee | — | — | ||
 I-69
|
23.390 | 37.643 | MS 304 / MS 713 east of Banks | I-55 north of Hernando | — | — | Present highway co-signed with I-55 from eastern terminus to Tennessee state line. Proposed section to run from western terminus using existing US 61 roadbed to Greenville Bridge near Refuge | |
Auxiliary highways
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 I-110
|
4.10 | 6.60 | US 90 in Biloxi | I-10 in D'Iberville | 1988 | current | ||
 I-220
|
12.01 | 19.33 | I-20 in Jackson | I-55 in Ridgeland | 1981 | current | Beltway around northwestern Jackson | |
 I-269
|
23.79 | 38.29 | I-55 / I-69 in Hernando | I-269 at the Tennessee state line near Southaven | 2015 | current | Outer beltway of Memphis, northern beltway in Tennessee signed as SR 385 | |
 Future I-310
|
6 | 9.7 | US 90 in Gulfport | I-10 in Gulfport | proposed | — | Proposed connector to the w:Port of Gulfport; also has the designation of MS 601 | |