South Carolina Highway 72 (disambiguation)
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South Carolina Highway 72 may refer to:
- South Carolina Highway 72, a state highway from a point southwest of Calhoun Falls to Rock Hill
- South Carolina Highway 72 (1920s–1930s), a former state highway from a point south of Waterloo to a point in Waterloo
- South Carolina Highway 72 (1940s), a former state highway from a point near Leeds to a point in Leeds