South Carolina Highway 28 Business
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South Carolina Highway 28 Business may refer to:
- South Carolina Highway 28 Business (Abbeville), a former business loop in Abbeville
- South Carolina Highway 28 Business (Anderson), a business loop in Anderson
- South Carolina Highway 28 Business (Clemson), a former business loop in Clemson
- South Carolina Highway 28 Business (Pendleton), a business loop in Pendleton
- South Carolina Highway 28 Business (Seneca), a former business loop in Seneca